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In a clinical setting, vitamin B12 injections are rarely administered on a per day basis for long-term maintenance

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MDSCs, a heterogeneous population derived from immature bone marrow, serve as precursors of mature monocytes/DCs/granulocytes and are key cells promoting tumor proliferation and immune suppression (124)

According to some embodiments, the therapeutic amount of the Silybum marianum active ingredient is from about 10 mg to about 200 mg for daily administration to the subject in need thereof

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